Collie Family Breeds--Inherited Disorders Reported
 
Inherited disorders reported in collie-related breeds, compiled from the tables in Dr. Padgett's Control of Canine Genetic Diseases.
Padgett's tables are sourced from diagnoses officially reported to the vet research community in the form of published research papers as well as Vet Medical Data Base (VMDB), Canine Eye Research Foundation (CERF), and in some cases based on diagnosis performed at Michigan State University vet hospital where Dr. Padgett works.

Please be careful to refrain from leaping to unwarranted conclusions based on this data. There is a lot this data can tell you, and there is a lot that it can't tell you.

FIRST CAUTION: INCIDENCE RATES
This data does NOT establish incidence rate (how many dogs are affected with a particular disorder in a particular breed). In some cases a disorder on this list may be due to a single reported case in the entire history of the breed in the databases. In other cases the incidence rate may be known to be high for some disorder in some breed, due to either breed surveys by breed clubs, or scientific research studies specifically designed to establish incidence rate of the problem in the breed. But in either case, the incidence rate of these problems, by breed, is not reported in Padgett's book and is not reported here.

Incidence rate of inherited disorders is extremely important (among other things) for deciding what is the best approach to take for controlling the problem in a breed. Control of genetic disorders is not a one-size-fits-all sort of thing. A breed with a high incidence rate of some particular problem may require very different management approach than one with low incidence rate of the same problem. Unfortunately, at this time, there is little or no reliable assessment of incidence rates of most genetic disorders in most breeds.

SECOND CAUTION: UNREPORTED CASES
This data CANNOT establish that any particular disorder is NOT found in a breed. It only establishes whether the disorder has been found in some member(s) of a breed and reported as such to the research community. For any breed, many disorders that might occur in the breed may go undiagnosed or, if diagnosed by a local vet, may not get reported to the VMDB. For breeds with a larger population there is likely to have been a reasonably high probability for at least some affected individuals to be diagnosised through vet teaching hospitals that report data to VMDB over the last 20 years.  But for breeds of small population, the probability of a diagnosis being report to the vet research community may very well be much lower. Unless, as with the Portuguese Water Dog, a very strong breed club education and research funding effort has already made the breed stand out as one of the small populations in which a concerted effort has been made over several generations to work with vet researchers to accumulate data and learn a great deal about the breed's genetic disorders (and how to control them).

THIRD CAUTION: DIAGNOSIS CONSISTENCY AND RELIABILITY
Is the diagnosis protocol for any particular disorder so clear and precise that all and only dogs that truly have a particular disorder, are found to have that disorder? This is particularly important to think about when pondering whether some disorder might be on the rise in a breed. Maybe the disorder is not increasing or decreasing, but the diagnosis and reporting is.

Often a reasonably observant person with no vet training can see that something is wrong with their dog. That person may be able to go a long ways towards figuring out what the problem is. But for many inherited disorders, a professional diagnosis is necessary to be sure. For example, there might be 6 different genetic causes of deafness, and all are inherited in different ways so successful control of inherited deafness in a breed will depend to some extent on that precise diagnosis.

And even within the vet community there may be disagreements on diagnosis as well as different skill levels for making a diagnosis.
Some disorders might have too imprecise a definition at this time for all vets to agree on diagnosis. For example, one wonders about the definition of "Excessive Agressiveness". Is it well defined in the vet and vet research community?

FOURTH CAUTION: INHERITED OR NOT
Dr. Padgett includes disorders that are presumed to be inherited at this time. For many disorders listed, there may be very little to go on as to whether the disorder is really inherited or whether there is an environmental cause. There are some cases where an environmental cause (such as a heavy metal or chemical contaminant) causes precisely the same phenotypic anomaly as does a known genetic problem. How to tell them apart, in a particular case? To complicate matters further, in some cases it may be that there is both an inherited and an environmental component.

It may turn out in the future that some of these listed disorders are found out not to be inherited. Also, more disorders that are found to be inherited will undoubtedly be added to the list in the future.

Please note that I take full credit for typos, as I transferred this information by hand from the extensive tables in Dr. Padgett's book. Please don't base important decisions on the data contained in this  web page. At least read Dr. Padgett's book and confirm what I've typed here. Also be sure to discuss any medical concerns you have about your own dogs with your own vet.

The number in front of the name of the disease is the number by which it is listed in Padgett's book.
 
Disease / disorder 81 47 2 43 32 72 20 8
Alimentary Collie Aussie ES BC Beardie Sheltie ACD Kelpie
2 Acute Hemorrhagic Entropathy X
3 Adenomatous Polygeniceps X
6 Canine Sprue X
13 Gastric Dilation-Volvulous X
16 Idiopathic Canine Colitis X X
19B Megaesophagus X
20 Perianal Fistula X
Behavioral Collie Aussie ES BC Beardie Sheltie ACD Kelpie
Excessive Aggressiveness X X X X
Endocrine Collie Aussie ES BC Beardie Sheltie ACD Kelpie
5B Hypothroidism X X X X X X X X
Hearing / Balance Collie Aussie ES BC Beardie Sheltie ACD Kelpie
1 Deafness X X X X X
Hematopoietic / Lymphatic Collie Aussie ES BC Beardie Sheltie ACD Kelpie
3 Border Collie Neutropenia X
4 Canine Cyclic Neutropenia X
10 Dysfibrinogen-emia X
18 Glanzmann's Thrombasthenia X
20 Hemophelia A X X
21 Hemophilia B X
25 Hypofibrino-genemia X
31 Pelger-Huet Anomaly X X
41B Type III von Willebrand's Disease X
41C von Willebrand's Disease X* X
Heart / Vascular Collie Aussie ES BC Beardie Sheltie ACD Kelpie
6 Dilated Cardiomyopathy X
7 Endocardiosis X
13 Patent Ductus Arteriosus X X X X X
15 Persistent Right Aortic Arch X
16 Pulmonic Stenosis X
18 Subaortic Stenosis X X
21 Ventricular Septal Defect X X
Immune System Collie Aussie ES BC Beardie Sheltie ACD Kelpie
1 Atopic Dermatitis X X X
2 Autoimmune Hemolytic Anemia X X
6 Demodicosis X X X
7 Discoid Lupus Erythematosus X X
9 Immune Mediated Polygenic Arthritis X X
11 Rheumatoid Arthritis X X
15 Systemic Lupus Erythematosus X X X X
Integumentary Collie Aussie ES BC Beardie Sheltie ACD Kelpie
6B Color Dilution Alopecia X
8 Black Hair Folicular Dysplasia X X
9 Bullous Pemphigoid X X
12 Collagen Disorder of the Footpads X
20 Dermatomyositis X X X
24 Ehlers Danlos Syndrome X
26 Epidermolysis Bullosa X X
33B Ichthyosis X
36 Idiopathic Ulcerative Dermatosis X X
37 Inquinal Hernia X X X
46 Pemphigus Erythematosus X X
47 Pemphigus Foliaceus X X X
48 Pemphigus Vulgaris X
49 Perineal Hernia X X X
50 Powder-Puff X
51B Primary Seborrhea X
52 Schistosomus Reflexus X
53B Sebatious Adenitis X X
58 Subcorneal Pustular Dermatosis X
63 Umbilical Hernia X X X X
64 Vitiligo X
Liver / Pancreas Collie Aussie ES BC Beardie Sheltie ACD Kelpie
3B Diabetes Mellitus X
4 Lobular Dissecting Heepatitis X
5 Pancreatic Hypoplasia X
6B Portosystemic Shunt, Extrahepatic X X X X
7 Portosystemic Shunt, Intrahepatic X
Muscle Collie Aussie ES BC Beardie Sheltie ACD Kelpie
1 Biceps Brachii Tendon Displacement X
5 Eosinophilic Myositis X
11 Malignant Hyperthermia X
13 Mitochondrial Myopathy X
19 X-linked Myopathy X
Neurological Collie Aussie ES BC Beardie Sheltie ACD Kelpie
7 Cerebellar Degeneration X X X
8 Cerebellar Vermian Hypoplasia X
10 Ceroid-Lipofuscinosis X X
14 Degenerative Myelopathy X
16 Distal Neuropathy X
18 Dysautonomia X X
19B Epilepsy X X X X X
37 Idiopathic Meningitis X
46 Neuroaxonal Dystrophy X X
53 Sensory Ganglio-radiculitis X
54B Sensory Neuropathy X
56 Spinal Dysraphism X
57G Spinal Muscular Atrophy X
Ocular Collie Aussie ES BC Beardie Sheltie ACD Kelpie
3 Blepharo-phimosis X X
5H Cataracts X X X X X X
6C Central Progressive Retinal Atrophy X X
7 Choroidal Hypoplasia X
8A Collie Eye Anomaly  X X X X
9 Coloboma of the Eyelid or Iris X
11D Corneal Dystrophy, polygenic X
11E Corneal Dystrophy, undetermined X X X X
14 Dermoid X
15 Distichiasis X X X
16 Ectopic cilia X
19 Enophthalmos X
20 Entropion X X X
23C Glaucoma X X X
25 Hetrochromia Iridis X X
26 Imperforate Lacrimal Punctum X
27 Keratocon-junctivitis Sicca X X X X
29A Lens Luxation, recessive X
29C Lens Luxation, undetermined X X
32 Microcornea X X
33B Microphthalmia X X X
35 Optic Nerve Hypoplasia X X X
36 Pannus X X X X
38 Persistent Pupillary Membranes X X X X X
41A Progressive Retinal Atrophy, recessive X
41B Progressive Retinal Atrophy, undetermined X X X X X X
43Protrusion of the Third Eyelid X
44B Retinal Dysplasia, Folds X X X X
45 Retinal Dysplasia, Geographic Detachment X X X
50 Trichiasis X X
52 Uveodermatologic Syndrome X X
Reproductive Collie Aussie ES BC Beardie Sheltie ACD Kelpie
2 Cryptorchidism X X X X
Respiratory Collie Aussie ES BC Beardie Sheltie ACD Kelpie
6 Primary Ciliary Dyskenesia X
Skeletal Collie Aussie ES BC Beardie Sheltie ACD Kelpie
3 Australian Shepherd Lethal Skeletal Defect Syndrome X
7 Calcinosis Circumscripta X X
9B Cleft Lip / Cleft Palate X
10 Cranio-mandibular Osteopathy X
13B Australian Shepherd Dwarfism X
13S Dwarfism X X X
20 Hip Dysplasia X X X X X X X X
21 Hypertrophic Osteodystrophy X
25 Legg-Perthes X
30 Luxation of the Elbow X X
31 Luxation of the Patella X X X X X
33 Luxation of the Superficial Digital Flexor Tendon X X
34 Luxation of the Hock X X
35 Missing Teeth X
36 Multiple Cartilaginous Exostoses X X
41A Osteochondritis Dissecans-

FCP

X X X X X
41C Osteochondritis Dissecans - Hock Joint X
41D Osteochondritis Dissecans - Shoulder Joint X X
41E Osteochondritis Dissecans - Stifle Joint X X
41F Osteochondritis Dissecans - Tarsocrural Joint X
45B Overshot X X
46 Panosteitis X X
48 Premature Closure of the Tibia X X
49 Premature Closure of the Ulna X
50 Premature Closure of the Radius X X
54 Sesamoid Disease X
64 Undershot X X X
Urinary Collie Aussie ES BC Beardie Sheltie ACD Kelpie
2 Ectopic Ureters X X X
5 Fanconi's Syndrome X
9C Polygenic Cystic Kidney X
12 Renal Aplasia X
13B Renal Dysplasia X

*Padgett does not list the Collie breed as having vWD officially reported, but via personal correspondence with Dr. Brooks who does research on vWD at Cornell, I learned that vWD is definitely known in the Collie breed, apparently the dominant-inherited form.